Ramachandran Anup, Schuettler Martin, Lago Natalia, Doerge Thomas, Koch Klaus Peter, Navarro Xavier, Hoffmann Klaus-Peter, Stieglitz Thomas
Department of Medical Engineering and Neuroprosthetics, Fraunhofer-IBMT, Ensheimer Str. 48, 66386 St. Ingbert, Germany.
J Neural Eng. 2006 Jun;3(2):114-24. doi: 10.1088/1741-2560/3/2/005. Epub 2006 Apr 18.
This paper reports on the design, in vitro and in vivo investigation of a flexible, lightweight, polyimide based implantable sieve electrode with a hybrid assembly of multiplexers and polymer encapsulation. The integration of multiplexers enables us to connect a large number of electrodes on the sieve using few input connections. The implant assembly of the sieve electrode with the electronic circuitry was verified by impedance measurement. The 27 platinum electrodes of the sieve were coated with platinum black to reduce the electrode impedance. The impedance magnitude of the electrode sites on the sieve (geometric surface area 2,200 microm(2)) was |Z(f=1kHz)| = 5.7 kOmega. The sieve electrodes, encased in silicone, have been implanted in the transected sciatic nerve of rats. Initial experiments showed that axons regenerated through the holes of the sieve and reinnervated distal target organs. Nerve signals were recorded in preliminary tests after 3-7 months post-implantation.
本文报道了一种基于聚酰亚胺的柔性、轻质可植入筛状电极的设计、体外和体内研究，该电极具有多路复用器的混合组件和聚合物封装。多路复用器的集成使我们能够使用较少的输入连接来连接筛状电极上的大量电极。通过阻抗测量验证了筛状电极与电子电路的植入组件。筛状电极的27个铂电极涂有铂黑以降低电极阻抗。筛状电极部位（几何表面积2200平方微米）的阻抗幅值为|Z(f = 1kHz)| = 5.7千欧。包裹在硅树脂中的筛状电极已植入大鼠横断的坐骨神经中。初步实验表明，轴突通过筛孔再生并重新支配远端靶器官。植入后3 - 7个月的初步测试中记录到了神经信号。
