Stieglitz T, Poessnecker J, Rosahl S K, Haastert K, Brinker T, Meyer J U
Fraunhofer-Institut für Biomedizinische Technik, St. Ingbert, Deutschland.
Biomed Tech (Berl). 2002;47 Suppl 1 Pt 2:692-5. doi: 10.1515/bmte.2002.47.s1b.692.
Since more than 20 years, nerve stumps have been interfaced with sieve-like microsystems with integrated electrodes in experimental studies. In most cases, silicone tubes have been assembled on the microsystems to adapt the nerve and deliver a guidance structure for regeneration. Flexible, polyimide-based sieve electrodes with integrated fixation aids have been implanted chronically in an animal model. They have been adapted between the transsected ends of the sciatic nerve of rats and on the proximal stump in an amputation model. First electrophysiological experiments proved the functional reinnervation. Combining embryonic motor neurons with the sieve electrode, we propose a biohybrid system that is under investigation to functionally interface the distal part of a transsected peripheral nerve.
二十多年来，在实验研究中，神经残端已与带有集成电极的筛状微系统相连接。在大多数情况下，硅胶管已被组装在微系统上，以适配神经并为再生提供引导结构。带有集成固定辅助装置的柔性聚酰亚胺基筛状电极已长期植入动物模型中。它们已被适配于大鼠坐骨神经的横断端之间以及截肢模型的近端残端上。首次电生理实验证明了功能再支配。将胚胎运动神经元与筛状电极相结合，我们提出了一种生物混合系统，目前正在对其进行研究，以在功能上连接横断外周神经的远端部分。
