De Groote Mary A, Huitt Gwen
University of Colorado, Boulder, Colorado, USA.
Clin Infect Dis. 2006 Jun 15;42(12):1756-63. doi: 10.1086/504381. Epub 2006 May 11.
Rapidly growing mycobacteria, generally of low virulence, are capable of causing a wide spectrum of infections. Increasing reports in the literature, referral center experiences, and data from the Infectious Disease Society of America Emerging Infectious Disease Network suggest that greater numbers of infections are occurring. Epidemiological study is imperative in understanding the true incidence of these infections and preventing disease in vulnerable hosts. Especially problematic is pulmonary infection due to Mycobacterium abscessus, which is difficult to cure. New agents with enhanced activity against this group and other nontuberculous mycobacteria are needed. Here, we focus on the members of the rapidly growing mycobacteria because of their emerging importance in both sporadic infections and outbreak settings.
快速生长分枝杆菌通常毒力较低，但能够引起广泛的感染。文献中越来越多的报道、转诊中心的经验以及美国传染病学会新发传染病网络的数据表明，此类感染的发生数量正在增加。开展流行病学研究对于了解这些感染的真实发病率以及预防易感宿主发病至关重要。尤其成问题的是脓肿分枝杆菌引起的肺部感染，这种感染难以治愈。需要有对该菌群及其他非结核分枝杆菌活性增强的新型药物。在此，我们重点关注快速生长分枝杆菌的成员，因为它们在散发性感染和暴发疫情中日益重要。
