希腊HIV感染患者中乙型和丙型肝炎病毒感染的血清学特征及病毒学评估

Serological profile and virological evaluation of hepatitis B and hepatitis C virus infection among HIV infected patients in Greece.

作者信息

Elefsiniotis loannis S, Paparizos Vassilios, Botsi Chrysoula, Pantazis Konstantinos D, Katsambas Andreas

机构信息

Department of Internal Medicine, Hepatology Unit, Hippokration Hospital of Athens, Athens, Greece.

出版信息

Cent Eur J Public Health. 2006 Mar;14(1):22-4. doi: 10.21101/cejph.b0047.

DOI:10.21101/cejph.b0047

PMID:16705877

Abstract

In this study we evaluate the prevalence of HBV and HCV infections and the HBV and/or HCV viral load as well as HCV genotype among 737 HIV-infected patients. 89/737 (12.1%) were HBsAg(+) and the majority of them (60.7%) were HBeAg(+), in contrast to general Greek population; anti-HBc seropositivity was detected in 48.1% of the study population. Serum HBV-DNA levels were 5.75 +/- 1.66 (-log 10 copies/ml) and HBeAg(+) coinfected patients had significantly higher levels than HBeAg(-) ones (7.40 +/- 0.64 vs 4.59 +/- 1.01, respectively, p < 0.001). 8.2% of HIV-infected patients were anti-HCV(+) and the majority of them (85.7%) had HCV-RNA levels more than 700.000 IU/I. The most common HCV-genotype was genotype-1 (12/28, 42.9%), representing a difficult-to-treat special population.

摘要

在本研究中，我们评估了737例HIV感染患者中HBV和HCV感染的患病率、HBV和/或HCV病毒载量以及HCV基因型。89/737（12.1%）为HBsAg阳性，其中大多数（60.7%）为HBeAg阳性，这与希腊普通人群不同；48.1%的研究人群检测到抗-HBc血清阳性。血清HBV-DNA水平为5.75±1.66（-log10拷贝/ml），HBeAg阳性合并感染患者的水平显著高于HBeAg阴性患者（分别为7.40±0.64和4.59±1.01，p<0.001）。8.2%的HIV感染患者抗-HCV阳性，其中大多数（85.7%）的HCV-RNA水平超过700,000 IU/I。最常见的HCV基因型是1型（12/28，42.9%），代表了一个难以治疗的特殊人群。