Elefsiniotis loannis S, Paparizos Vassilios, Botsi Chrysoula, Pantazis Konstantinos D, Katsambas Andreas
Department of Internal Medicine, Hepatology Unit, Hippokration Hospital of Athens, Athens, Greece.
Cent Eur J Public Health. 2006 Mar;14(1):22-4. doi: 10.21101/cejph.b0047.
In this study we evaluate the prevalence of HBV and HCV infections and the HBV and/or HCV viral load as well as HCV genotype among 737 HIV-infected patients. 89/737 (12.1%) were HBsAg(+) and the majority of them (60.7%) were HBeAg(+), in contrast to general Greek population; anti-HBc seropositivity was detected in 48.1% of the study population. Serum HBV-DNA levels were 5.75 +/- 1.66 (-log 10 copies/ml) and HBeAg(+) coinfected patients had significantly higher levels than HBeAg(-) ones (7.40 +/- 0.64 vs 4.59 +/- 1.01, respectively, p < 0.001). 8.2% of HIV-infected patients were anti-HCV(+) and the majority of them (85.7%) had HCV-RNA levels more than 700.000 IU/I. The most common HCV-genotype was genotype-1 (12/28, 42.9%), representing a difficult-to-treat special population.
在本研究中，我们评估了737例HIV感染患者中HBV和HCV感染的患病率、HBV和/或HCV病毒载量以及HCV基因型。89/737（12.1%）为HBsAg阳性，其中大多数（60.7%）为HBeAg阳性，这与希腊普通人群不同；48.1%的研究人群检测到抗-HBc血清阳性。血清HBV-DNA水平为5.75±1.66（-log10拷贝/ml），HBeAg阳性合并感染患者的水平显著高于HBeAg阴性患者（分别为7.40±0.64和4.59±1.01，p<0.001）。8.2%的HIV感染患者抗-HCV阳性，其中大多数（85.7%）的HCV-RNA水平超过700,000 IU/I。最常见的HCV基因型是1型（12/28，42.9%），代表了一个难以治疗的特殊人群。
