Liu Yingxi, Zhang Jun, Zhao Wenzhi, Sun Xiuzhen, Sun Xiaojiang
State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Apr;23(2):318-21.
Presented is a method to set up a quantification model of bone growing and remodeling adaptation, which integrates animal experiments, parameter identification of mathematical functions and technique of computer simulation. By designing a new animal experiment, we investigate the effects of growing and remodeling of the rat femurs in different stress environments, gather the bone mineral density (BMD) of proximal femur in the same interval for the unknown parameter (B and K) inversion of bone growing and remodeling equation and create the femur three-dimensional geometrical model based on CT images. The model in this paper can not only numerically measure the relation between outer stimulus and the femur BMD variation of rapid growing rats, but also predict the growth trend of rat femur under different stress environments in its whole lifecycle. The thought and method of creating the model in this paper can be used for reference to modeling human bone growth and remodeling.
本文提出了一种建立骨生长与重塑适应量化模型的方法，该方法整合了动物实验、数学函数的参数识别和计算机模拟技术。通过设计一项新的动物实验，我们研究了不同应力环境下大鼠股骨生长与重塑的影响，收集同一时间间隔内股骨近端的骨密度（BMD），用于骨生长与重塑方程未知参数（B和K）的反演，并基于CT图像创建股骨三维几何模型。本文中的模型不仅可以数值测量快速生长大鼠的外部刺激与股骨BMD变化之间的关系，还可以预测大鼠股骨在不同应力环境下整个生命周期的生长趋势。本文创建模型的思路和方法可为人体骨生长与重塑建模提供参考。
