Potra Florian A, Liu Xing, Seillier-Moiseiwitsch Françoise, Roy Anindya, Hang Yaming, Marten Mark R, Raman Babu, Whisnant Carol
Department of Mathematics and Statistics, University of Maryland, Baltimore, MD 21250, USA.
J Comput Biol. 2006 Apr;13(3):614-30. doi: 10.1089/cmb.2006.13.614.
We present a new approach for aligning families of 2D gels. Instead of choosing one of the gels as reference and performing a pairwise alignment, we construct an ideal gel that is representative of the entire family and obtain a set of piecewise affine transformations that optimally align each gel of the family to the ideal gel. The coefficients defining the transformations as well as the ideal landmarks are obtained as the solution of a large-scale quadratic programming problem that can be solved efficiently by interior-point methods.
我们提出了一种用于二维凝胶图谱比对的新方法。我们不是选择其中一张凝胶作为参考并进行成对比对，而是构建一个代表整个家族的理想凝胶，并获得一组分段仿射变换，以将家族中的每张凝胶最优地比对到理想凝胶上。定义变换的系数以及理想地标点是通过一个大规模二次规划问题的解得到的，该问题可以通过内点法有效地求解。
