Piamphongsant Thada
Skin and Allergy Clinic, Bangkok, Thailand.
Dermatol Surg. 2006 May;32(5):611-7; discussion 617. doi: 10.1111/j.1524-4725.2006.32131.x.
Deep type of melasma is difficult to treat. Various compositions for peeling have been formulated to accomplish this.
Our purpose was to determine the safe use of the new formula, which was composed of phenol and castor oil.
Different concentrations of phenol and castor oil were mixed in five formulations, and the solutions were tested on the forearms of 10 volunteers. The application time was 1 minute, different from that of the original phenol-croton oil. Formula 4 was found to cause a high effect of peeling with least side effects and was used to treat deep facial melasma in 30 patients.
Higher concentrations of castor oil produced more inflammation when mixed with phenol. Formula 4 was used to clear two cases of melasma in 1 week despite no effect from prior use of a modified antimelasma cream, while some degree of fading was noted in other cases. The total number of different melasma indices was reduced from 206.4 to 91.2 in 30 patients. Hyperpigmentation was noted in five cases and hypopigmentation in one case. Neither scar formation nor cardiac arrhythmia was observed.
A phenol-castor oil peel with an application time of 1 minute reduces pigments in the deep type of melasma with least side effects and a high efficiency when combined with an antimelasma cream. The safe formula and the technique of application are introduced.
深层黄褐斑难以治疗。为此已配制了各种用于剥脱的组合物。
我们的目的是确定由苯酚和蓖麻油组成的新配方的安全使用方法。
将不同浓度的苯酚和蓖麻油混合在五种配方中，并在10名志愿者的前臂上进行测试。涂抹时间为1分钟，与原来的苯酚-巴豆油不同。发现配方4引起的剥脱效果高且副作用最小，并用于治疗30例面部深层黄褐斑患者。
蓖麻油浓度较高时与苯酚混合会产生更多炎症。尽管之前使用改良的抗黄褐斑乳膏无效，但配方4在1周内清除了2例黄褐斑，而其他病例则有一定程度的色素减退。30例患者不同黄褐斑指数的总数从206.4降至91.2。5例出现色素沉着过度，1例出现色素沉着不足。未观察到瘢痕形成或心律失常。
涂抹时间为1分钟的苯酚-蓖麻油剥脱术与抗黄褐斑乳膏联合使用时，能减少深层黄褐斑的色素沉着，副作用最小且效率高。介绍了安全配方和应用技术。
