对于I期乳腺癌患者前哨淋巴结转移的术中评估，冰冻切片优于印片细胞学检查。
Frozen section is superior to imprint cytology for the intra-operative assessment of sentinel lymph node metastasis in stage I breast cancer patients.
作者信息
Mori Miki, Tada Keiichiro, Ikenaga Motoko, Miyagi Yumi, Nishimura Seiichiro, Takahashi Kaoru, Makita Masujiro, Iwase Takuji, Kasumi Fujio, Koizumi Mituru
机构信息
Department of Breast Surgery, Cancer Institute Hospital, Tokyo, Japan.
出版信息
World J Surg Oncol. 2006 May 17;4:26. doi: 10.1186/1477-7819-4-26.
Abstract
BACKGROUND
A standard intra-operative procedure for assessing sentinel lymph node metastasis in breast cancer patients has not yet been established.
PATIENTS AND METHODS
One hundred and thirty-eight patients with stage I breast cancer who underwent sentinel node biopsy using both imprint cytology and frozen section were analyzed.
RESULTS
Seventeen of the 138 patients had sentinel node involvement. Results of imprint cytology included nine false negative cases (sensitivity, 47.1%). In contrast, only two cases of false negatives were found on frozen section (sensitivity, 88.2%). There were two false positive cases identified by imprint cytology (specificity, 98.3%). On the other hand, frozen section had 100% specificity.
CONCLUSION
These findings suggest that frozen section is superior to imprint cytology for the intra-operative determination of sentinel lymph node metastasis in stage I breast cancer patients.
摘要
背景
尚未建立用于评估乳腺癌患者前哨淋巴结转移的标准术中程序。
患者与方法
对138例接受前哨淋巴结活检（采用印片细胞学检查和冰冻切片检查）的I期乳腺癌患者进行分析。
结果
138例患者中有17例存在前哨淋巴结受累。印片细胞学检查结果包括9例假阴性病例（敏感性为47.1%）。相比之下，冰冻切片仅发现2例假阴性病例（敏感性为88.2%）。印片细胞学检查发现2例假阳性病例（特异性为98.3%）。另一方面，冰冻切片的特异性为100%。
结论
这些结果表明，在I期乳腺癌患者术中确定前哨淋巴结转移方面，冰冻切片优于印片细胞学检查。
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