胎羊肢体羊膜带综合征。I：肢体截肢的实验模型。
Extremity amniotic band syndrome in fetal lamb. I: An experimental model of limb amputation.
作者信息
Soldado F, Peiró J L, Aguirre M, Moll X, García-Fontecha C, Giné C, Martínez-Ibáñez V
机构信息
Paediatric Orthopaedic Surgery Unit, Department of Orthopaedic Surgery, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
出版信息
Am J Obstet Gynecol. 2006 Dec;195(6):1607-10. doi: 10.1016/j.ajog.2006.03.056. Epub 2006 May 16.
OBJECTIVE
The objective of the study was to reproduce severe forms of extremity amniotic bands, which result in amputation or severe lesions.
STUDY DESIGN
Right limbs of 5 60-day gestational age pregnant sheep were ligated with silk suture at the infracondylar level. Left limbs were used for paired comparison. The limbs obtained from term fetuses were analyzed morphologically, radiologically, and histologically.
RESULTS
The ligated limbs showed an amputation or quasiamputation. Four extremities showed a necrotic pattern and 4 an edema pattern.
CONCLUSION
A model of severe extremity amniotic bands that reproduces the effect of the extremity amniotic bands in the human fetus was developed. Future applications of this new model could be an experimental study of in utero salvage of limbs affected with severe extremity amniotic bands in the ovine fetus.
目的
本研究的目的是重现导致截肢或严重损伤的严重肢体羊膜带形式。
研究设计
对5只妊娠60天的孕羊的右肢在髁下水平用丝线结扎。左肢用于配对对照。对足月胎儿的肢体进行形态学、放射学和组织学分析。
结果
结扎肢体出现截肢或准截肢。4个肢体呈现坏死模式，4个呈现水肿模式。
结论
建立了一种严重肢体羊膜带模型，该模型再现了人类胎儿肢体羊膜带的影响。这个新模型未来的应用可能是对羊胎儿中受严重肢体羊膜带影响的肢体进行宫内挽救的实验研究。
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