Mitani Hideaki, Shirayama Yukihiko, Yamada Takeshi, Maeda Kazuhisa, Ashby Charles R, Kawahara Ryuzou
Department of Neuropsychiatry, Faculty of Medicine, Tottori University, 36-1 Nishi-machi, Yonago, Tottori 683-8504, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1155-8. doi: 10.1016/j.pnpbp.2006.03.036. Epub 2006 May 16.
The goal of this study was to evaluate the utility of using plasma levels of amino acids as an indicator of the severity of depression. The samples were collected from 23 depressed patients receiving antidepressant medication, and were compared to 31 healthy subjects. The plasma levels of amino acids were determined using HPLC with fluorometric detection. The severity of depression was evaluated using the Hamilton Depression Rating Scale (HAM-D) scores. Plasma levels of glutamate, glutamine, glycine and taurine were significantly increased in the depressed patients compared to the controls. Statistical analysis indicated a positive correlation between glutamate and alanine levels and HAM-D scores and a negative correlation of L-serine with HAM-D scores. The results indicate that plasma level of glutamate, alanine and L-serine could reflect the severity of depression rather than glutamine, glycine and taurine.
本研究的目的是评估使用血浆氨基酸水平作为抑郁症严重程度指标的效用。样本取自23名正在接受抗抑郁药物治疗的抑郁症患者，并与31名健康受试者进行比较。使用带荧光检测的高效液相色谱法测定血浆氨基酸水平。使用汉密尔顿抑郁评定量表（HAM-D）评分评估抑郁症的严重程度。与对照组相比，抑郁症患者血浆中的谷氨酸、谷氨酰胺、甘氨酸和牛磺酸水平显著升高。统计分析表明，谷氨酸和丙氨酸水平与HAM-D评分呈正相关，L-丝氨酸与HAM-D评分呈负相关。结果表明，谷氨酸、丙氨酸和L-丝氨酸的血浆水平可反映抑郁症的严重程度，而非谷氨酰胺、甘氨酸和牛磺酸。
