Ostrakhovitch Elena A, Ono Kenjiro, Yamasaki Tritia R
Department of Neurology, University of Kentucky, Lexington, KY 40536, USA.
Lexington VA Medical Center, Department of Neurology, Lexington, KY 40502, USA.
Metabolites. 2025 Mar 18;15(3):208. doi: 10.3390/metabo15030208.
Changes in the level of metabolites, small molecules that are intermediates produced by metabolism or catabolism, are associated with developing diseases. Metabolite signatures in body fluids such as plasma, cerebrospinal fluid, urine, and saliva are associated with Parkinson's disease. Here, we discuss alteration of metabolites in the TCA cycle, pentose phosphate pathway, kynurenic network, and redox system. We also summarize the efforts of many research groups to differentiate between metabolite profiles that characterize PD motor progression and dyskinesia, gait and balance, and non-motor symptoms such as depression and cognitive decline. Understanding how changes in metabolites lead to progression in PD may allow for the identification of individuals at the earliest stage of the disease and the development of new therapeutic strategies.
代谢物是新陈代谢或分解代谢产生的中间体等小分子，其水平变化与疾病发展相关。血浆、脑脊液、尿液和唾液等体液中的代谢物特征与帕金森病相关。在此，我们讨论三羧酸循环、磷酸戊糖途径、犬尿氨酸网络和氧化还原系统中代谢物的改变。我们还总结了许多研究小组为区分表征帕金森病运动进展和异动症、步态和平衡以及抑郁和认知衰退等非运动症状的代谢物谱所做的努力。了解代谢物变化如何导致帕金森病进展，可能有助于在疾病最早阶段识别个体并开发新的治疗策略。
