Irving Rachel C, Dickson Stuart J
Department of Chemistry, The University of Waikato, Knighton Road, Hamilton, New Zealand.
Forensic Sci Int. 2007 Feb 14;166(1):58-67. doi: 10.1016/j.forsciint.2006.03.027. Epub 2006 May 16.
Drug screening methods were developed to detect alprazolam, clobazam, clonazepam, diazepam, midazolam, oxazepam, temazepam, triazolam, zopiclone, and selected metabolites in human hair and nail samples employing liquid-liquid extraction and tandem liquid chromatography-mass spectrometry (LC-MS-MS). Hair and nail samples were obtained from patients who had recently discontinued or were currently prescribed one or more of the targeted drugs. Prazepam was used as the internal standard for all compounds. Some components in the hair matrix gave the same transitions as some of the analytes but did not compromise the analyses because their retention times differed from those for the target compounds. The analytical run time was 8-10min. Results of the hair analysis of a DFSA victim are also presented.
开发了药物筛查方法，采用液-液萃取和串联液相色谱-质谱联用（LC-MS-MS）技术检测人发和指甲样本中的阿普唑仑、氯巴占、氯硝西泮、地西泮、咪达唑仑、奥沙西泮、替马西泮、三唑仑、佐匹克隆及选定的代谢物。毛发和指甲样本取自近期停用或正在服用一种或多种目标药物的患者。普拉西泮用作所有化合物的内标。毛发基质中的一些成分与某些分析物具有相同的跃迁，但不会影响分析，因为它们的保留时间与目标化合物不同。分析运行时间为8 - 10分钟。还展示了一名药物辅助性侵受害者的毛发分析结果。
