Bilora Franca, Zanon Ezio, Petrobelli Francesco, Cavraro Monica, Prandoni Paolo, Pagnan Antonio, Girolami Antonio
Department of Medical and Surgical Sciences, 2nd Chair of Internal Medicine, University of Padua Medical School, Padua, Italy.
Clin Appl Thromb Hemost. 2006 Apr;12(2):193-8. doi: 10.1177/107602960601200207.
Whether carriers of hemophilia are protected against the development of atherosclerosis is controversial. In a case-control study, the presence of atherosclerosis was assessed and quantified with echo-color Doppler of all explorable arterial districts in 50 carriers of hemophilia and in 50 age-matched control individuals. All participants submitted to echo-color Doppler of carotid and femoral axis, of brachial arteries, and of the abdominal aorta. The presence and grade of atherosclerotic plaques were assessed, as well as the intima-media thickness (IMT). At least one atherosclerotic plaque was found in six cases (12.0%) versus 15 controls (30.0%); referring to the total number of plaques, 30% of them were evaluated in patients affected by decreased coagulation while 70% in subjects with normal levels of FVIII. In all the examined districts, the mean IMT was significantly lower in patients with hemophilia than in controls. Hemophilia protects against asymptomatic atherosclerosis.
血友病携带者是否能预防动脉粥样硬化的发生存在争议。在一项病例对照研究中，对50名血友病携带者和50名年龄匹配的对照个体的所有可探测动脉区域进行了彩色多普勒超声检查，以评估和量化动脉粥样硬化的存在情况。所有参与者均接受了颈动脉和股动脉轴、肱动脉以及腹主动脉的彩色多普勒超声检查。评估了动脉粥样硬化斑块的存在情况和分级，以及内膜中层厚度（IMT）。在6例（12.0%）患者中发现至少一个动脉粥样硬化斑块，而在15名对照者中（30.0%）发现；就斑块总数而言，30%在凝血功能下降的患者中评估，70%在FVIII水平正常的受试者中评估。在所有检查区域，血友病患者的平均IMT显著低于对照组。血友病可预防无症状性动脉粥样硬化。
