Badulescu Oana Viola, Badescu Minerva Codruta, Bojan Iris Bararu, Vladeanu Maria, Filip Nina, Dobreanu Stefan, Tudor Razvan, Ciuntu Bogdan-Mihnea, Tanevski Adelina, Ciocoiu Manuela
Department of Pathophysiology, Morpho-Functional Sciences (II), Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Department of Internal Medicine, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Diagnostics (Basel). 2024 Jan 29;14(3):286. doi: 10.3390/diagnostics14030286.
Hemophilia patients have a deficiency in or dysfunction of clotting factors, which can lead to a bleeding tendency. However, paradoxically, some hemophilia patients may also be at an increased risk of developing thrombotic events such as deep vein thrombosis or pulmonary embolism. The pathophysiology of thrombosis in hemophilia patients is not fully understood, but it is thought to involve a complex interplay of various factors, including the severity of the hemophilia, the presence of other risk factors such as obesity, smoking, or the use of hormonal therapies, and the presence of certain genetic mutations that increase the risk of thrombosis. In addition, it has been suggested that the use of clotting factor replacement therapy, which is a standard treatment for hemophilia, may also contribute to the development of thrombosis in some cases.
血友病患者存在凝血因子缺乏或功能障碍，这可能导致出血倾向。然而，矛盾的是，一些血友病患者发生深静脉血栓形成或肺栓塞等血栓事件的风险也可能增加。血友病患者血栓形成的病理生理学尚未完全明确，但据认为涉及多种因素的复杂相互作用，包括血友病的严重程度、肥胖、吸烟或使用激素疗法等其他危险因素的存在，以及某些增加血栓形成风险的基因突变的存在。此外，有人提出，作为血友病标准治疗方法的凝血因子替代疗法在某些情况下也可能促使血栓形成。
