O'Dea Denise, Handy Catherine M, Wexler Ann
St. Vincent's Comprehensive Cancer Center, New York, NY, USA.
Clin J Oncol Nurs. 2006 Apr;10(2):227-9. doi: 10.1188/06.CJON.227-229.
Ocular toxicity, although uncommon, can occur with many chemotherapeutic agents. Platinum compounds have been documented to produce a variety of ocular side effects, and reports have been made of ocular toxicity with oxaliplatin. This article reports on four patients who experienced ocular symptoms while receiving oxaliplatin. The symptoms included tunnel vision and visual loss with postural changes. One patient had objective findings that included papilledema. All of the changes were reversible. Oxaliplatin will continue to be used widely, so clinicians treating patients with it must be alert for unusual toxicities such as those described in this article.
眼部毒性虽然不常见，但许多化疗药物都可能引发。铂类化合物已被证明会产生多种眼部副作用，并且已有关于奥沙利铂导致眼部毒性的报道。本文报告了4例在接受奥沙利铂治疗时出现眼部症状的患者。症状包括管状视野和体位改变时的视力丧失。1例患者有包括视乳头水肿在内的客观体征。所有这些改变都是可逆的。奥沙利铂仍将被广泛使用，因此使用该药治疗患者的临床医生必须警惕本文所述的这类异常毒性。
