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A phase I dose-escalation study of oxaliplatin delivered via a laparoscopic approach using pressurised intraperitoneal aerosol chemotherapy for advanced peritoneal metastases of gastrointestinal tract cancers.一项关于奥沙利铂的I期剂量递增研究，该研究通过腹腔镜途径，采用加压腹腔内气溶胶化疗治疗胃肠道癌的晚期腹膜转移。
Eur J Cancer. 2020 Nov;140:37-44. doi: 10.1016/j.ejca.2020.09.010. Epub 2020 Oct 8.
2
Management of Oxaliplatin-Induced Peripheral Sensory Neuropathy.奥沙利铂所致周围感觉神经病变的管理
Cancers (Basel). 2020 May 27;12(6):1370. doi: 10.3390/cancers12061370.
3
Reversible Ocular Toxicity of Oxaliplatin: A Case Report.奥沙利铂的可逆性眼毒性：一例报告
Cureus. 2019 May 1;11(5):e4582. doi: 10.7759/cureus.4582.
4
Duration of Adjuvant Chemotherapy for Stage III Colon Cancer.III期结肠癌辅助化疗的疗程
N Engl J Med. 2018 Mar 29;378(13):1177-1188. doi: 10.1056/NEJMoa1713709.
5
Clinical Course of Oxaliplatin-Induced Neuropathy: Results From the Randomized Phase III Trial N08CB (Alliance).奥沙利铂所致神经病变的临床病程：III期随机试验N08CB（联盟研究）结果
J Clin Oncol. 2015 Oct 20;33(30):3416-22. doi: 10.1200/JCO.2014.58.8533. Epub 2015 Aug 17.
6
Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na(V)1.6-resurgent and persistent current.抗癌药物奥沙利铂通过钠通道亚型 Na(V)1.6 复燃和持续电流诱导急性降温加重的神经病。
Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6704-9. doi: 10.1073/pnas.1118058109. Epub 2012 Apr 9.
7
Oxaliplatin-Related Ocular Toxicity.奥沙利铂相关的眼部毒性
Case Rep Oncol. 2010 Nov 22;3(3):423-427. doi: 10.1159/000322675.
8
Oxaliplatin-induced neurotoxicity: changes in axonal excitability precede development of neuropathy.奥沙利铂诱导的神经毒性：轴突兴奋性的变化先于神经病变的发生。
Brain. 2009 Oct;132(Pt 10):2712-23. doi: 10.1093/brain/awp219. Epub 2009 Sep 10.
9
Management of oxaliplatin-induced peripheral neuropathy.奥沙利铂诱导的周围神经病的管理。
Ther Clin Risk Manag. 2005 Dec;1(4):249-58.
10
Ocular changes with oxaliplatin.奥沙利铂引起的眼部变化。
Clin J Oncol Nurs. 2006 Apr;10(2):227-9. doi: 10.1188/06.CJON.227-229.

短暂性视力丧失——一种罕见的奥沙利铂所致眼科副作用：两例报告

Transient Vision Loss - A Rare Oxaliplatin-Induced Ophthalmologic Side Effect: A Report of Two Cases.

作者信息

Ah-Thiane Loic, Raoul Jean-Luc, Hiret Sandrine, Senellart Hélène, Dumont Frédéric, Raimbourg Judith

机构信息

Department of Medical Oncology, Institut de Cancérologie de l'Ouest, Saint-Herblain, France.

Department of Surgical Oncology, Institut de Cancérologie de l'Ouest, Saint-Herblain, France.

出版信息

Case Rep Oncol. 2021 Mar 18;14(1):483-486. doi: 10.1159/000514656. eCollection 2021 Jan-Apr.

DOI:10.1159/000514656
PMID:33976624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8077355/
Abstract

Oxaliplatin, a platinum-based chemotherapeutic agent, is responsible for induced peripheral sensory neuropathy. Only a few cases of ophthalmologic toxicity have been reported. We report here two cases of sudden transient vision loss after oxaliplatin administration, in one case intraperitoneally. These symptoms likely reflect optic neuritis that could be included in the spectrum of oxaliplatin-induced neuropathy.

摘要

奥沙利铂是一种铂类化疗药物，可导致外周感觉神经病变。仅报告过少数几例眼科毒性病例。我们在此报告两例奥沙利铂给药后突然出现短暂视力丧失的病例，其中一例为腹腔内给药。这些症状可能反映了视神经炎，它可能属于奥沙利铂诱导的神经病变范畴。