Yang Chiou-Ying, Lee Yeong-Sheng, Huang Lan-Shiang, Kuo Yen-Liang, Liu Yi-Lun, Lu Cheng-Hsiung
From the Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan.
Scand J Infect Dis. 2006;38(4):273-80. doi: 10.1080/00365540500440379.
The geographic distribution of N. meningitidis is diverse. Information on the antigenic variation of N. meningitidis is important for the development of an outer membrane protein-based vaccine. As a first step towards vaccine development, serological typing was performed to determine the antigenic properties of 127 invasive N. meningitidis isolates collected in Taiwan between 1995 and 2002. With 31.5% non-serotypeable and 32.3% non-serosubtypeable, the 127 isolates fell into 51 phenotypes, with W135:NT:P1.5,2:L3,7,9, Y:14P1.5,2, and B:1:NST:L3,7,9 being the 3 most prevalent. Among the 37 serogroup B isolates, 15 serosubtypes were found, with P1.5,2 and P1.12,13 being the most prevalent. The high diversity of Por A among serogroup B isolates circulating in Taiwan poses a great challenge for the development of a PorA-based vaccine. Because 85% of the serogroup B isolates had the L3,7,9 immunotype, inclusion of L3,7,9 lipooligosaccharides in a PorA-based vaccine may be a promising approach. In addition, based on the phenotypic characterization, we suggest that both serogroup B and W135 isolates were endemic and that serogroup A, C, and Y isolates were imported, which may reflect increased international travel.
脑膜炎奈瑟菌的地理分布具有多样性。脑膜炎奈瑟菌抗原变异的信息对于基于外膜蛋白的疫苗开发至关重要。作为疫苗开发的第一步，我们进行了血清学分型，以确定1995年至2002年期间在台湾收集的127株侵袭性脑膜炎奈瑟菌分离株的抗原特性。这127株分离株中有31.5%不可血清分型，32.3%不可血清亚型分型，共分为51种表型，其中W135:NT:P1.5,2:L3,7,9、Y:14P1.5,2和B:1:NST:L3,7,9最为常见。在37株B群分离株中，发现了15种血清亚型，其中P1.5,2和P1.12,13最为常见。台湾地区流行的B群分离株中Por A的高度多样性对基于Por A的疫苗开发构成了巨大挑战。由于85%的B群分离株具有L3,7,9免疫型，在基于Por A的疫苗中包含L3,7,9脂寡糖可能是一种有前景的方法。此外，基于表型特征，我们认为B群和W135分离株为本地流行株，而A群、C群和Y群分离株为输入性，这可能反映了国际旅行的增加。
