Collier Edwin A, Davey Roger J, Black Simon N, Roberts Ron J
Molecular Materials Centre, School of Chemical Engineering and Analytical Science, The University of Manchester, PO Box 88, Sackville Street, Manchester M60 1QD, England.
Acta Crystallogr B. 2006 Jun;62(Pt 3):498-505. doi: 10.1107/S0108768106012018. Epub 2006 May 15.
The structures of two neutral and 17 salt forms of the base (1R, 2S)-(-)-ephedrine are reported. These structures are discussed in the light of the conformers of the ephedrine moiety, the existence of bilayers and the structure determining role of the counterions. Overall, most of the salt structures are essentially derived from the observed packing of the neutral base and are dominated by the amphiphilic nature of the ephedrine molecular structure. In a few cases the size and hydrophobicity of the counterion disrupts this behaviour.
报道了碱（1R，2S）-（-）-麻黄碱的两种中性形式和17种盐形式的结构。根据麻黄碱部分的构象异构体、双层的存在以及抗衡离子的结构决定作用对这些结构进行了讨论。总体而言，大多数盐结构基本上源自观察到的中性碱的堆积，并且由麻黄碱分子结构的两亲性主导。在少数情况下，抗衡离子的大小和疏水性会破坏这种行为。
