Cengiz Mustafa, Kafali Hasan, Artuc Hulya, Baysal Zeynep
Department of Anesthesiology and Reanimation, Harran University Medical School, Sanliurfa, Turkey.
Gynecol Obstet Invest. 2006;62(3):168-72. doi: 10.1159/000093427. Epub 2006 May 18.
BACKGROUND/AIMS: A hysterosalpingogram is an integral part of the evaluation of infertility, however, it is often painful.
We conducted a randomized double-blinded, placebo-controlled trial of intravenous infusion of remifentanil in women undergoing hysterosalpingography (HSG). We randomly allocated 62 patients scheduled for HSG to receive either a continuous infusion of 0.25 microg.kg(-1) of remifentanil or placebo. The degree of pain was documented via 10-cm visual analog scales (VAS). Patients' discomfort, side effects and recovery times were also recorded.
The VAS scores during HSG were 1.25 +/- 1.31 in the remifentanil group and 4.78 +/- 1.7 in the placebo group (p < 0.001). There were more patients in the remifentanil group that rated their condition as excellent (p < 0.001). The groups did not differ with regard to the incidence of side effects. The recovery times were found statistically longer in the remifentanil group (14 +/- 5 vs. 10 +/- 3 min). All the patients were discharged 30 min after the procedures without any side effects.
Remifentanil infusion during HSG is superior to placebo for relief of pain with minimal opioid side effects.
背景/目的：子宫输卵管造影是不孕症评估的一个重要组成部分，然而，它常常会引起疼痛。
我们对接受子宫输卵管造影（HSG）的女性进行了一项随机双盲、安慰剂对照试验，静脉输注瑞芬太尼。我们将62例计划进行HSG的患者随机分配，分别接受0.25μg·kg⁻¹瑞芬太尼持续输注或安慰剂。通过10厘米视觉模拟量表（VAS）记录疼痛程度。还记录了患者的不适、副作用和恢复时间。
HSG期间，瑞芬太尼组的VAS评分为1.25±1.31，安慰剂组为4.78±1.7（p<0.001）。瑞芬太尼组中更多患者将自己的状况评为优秀（p<0.001）。两组在副作用发生率方面没有差异。发现瑞芬太尼组的恢复时间在统计学上更长（14±5对10±3分钟）。所有患者在操作后30分钟出院，无任何副作用。
HSG期间输注瑞芬太尼在缓解疼痛方面优于安慰剂，且阿片类药物副作用最小。
