Oikawa T, Hosokawa M, Imamura M, Sendo F, Nakayama M
Clin Exp Immunol. 1977 Mar;27(3):549-54.
Growth of transplantable KMT-17 tumour in syngeneic WKA/MK rats was inhibited by i.v. preimmunization with whole blood from normal rats of allogeneic strains. The inhibitory effect was also observed in rats immunized with allogeneic white blood cells alone. The strength of the inhibitory effect mainly depended on the the strain of donor rat used; blood from Donryu and Kyoto strain rats produced the strongest inhibition, blood from Tokyo and Fischer strain rats produced moderate inhibition to the syngeneic tumour growth. Blood from ACI/N strain rats did not produce the inhibition. The mechanism of blood transfusion in inhibiting tumour growth is not yet clear. However, it seems that GVH reaction does not play an important role in the mechanism of the inhibition effect, because the effect was obtained by immunization with mitomycin C-treated allogeneic white blood cells and also by the immunization effect may be due to nonspecific active immunization. Significance of blood transfusion with special reference to clinical immunogtherapy of cancer is discussed.
用同种异体品系正常大鼠的全血进行静脉预免疫，可抑制同基因WKA/MK大鼠体内可移植性KMT - 17肿瘤的生长。在用同种异体白细胞单独免疫的大鼠中也观察到了这种抑制作用。抑制作用的强度主要取决于所用供体大鼠的品系；来自Donryu和京都品系大鼠的血液产生的抑制作用最强，来自东京和Fischer品系大鼠的血液对同基因肿瘤生长产生中等程度的抑制作用。来自ACI/N品系大鼠的血液未产生抑制作用。输血抑制肿瘤生长的机制尚不清楚。然而，移植物抗宿主反应（GVH反应）似乎在抑制作用机制中不起重要作用，因为用丝裂霉素C处理的同种异体白细胞免疫可获得这种效果，而且这种免疫效果可能归因于非特异性主动免疫。本文讨论了输血的意义，特别提及了癌症临床免疫治疗。
