Raine C S, Schaumburg H H, Snyder D H, Suzuki K
J Neurol Sci. 1975 May;25(1):29-41. doi: 10.1016/0022-510x(75)90184-7.
Detailed comparative ultrastructural examination of multiple sclerosis (MS) plaques, inflammatory CNS lesions from adreno-leukodystrophy(A-LD), tissue from a case of chronic granulomatous meningitis, biopsy samples of necrotic cerebral cortex and CNS tissue from a case of Kuf's disease (adult-type ceroid lipofuscinosis), has revealed that the intranuclear filamentous material previously thought to be related to a viral infection in MS is a non-specific finding. These intranuclear strands were, however, found in greatest frequency in the acute lesions of MS and were absent from chronically demyelinated areas. The macrophages, lymphocytes and fibrocytes containing filamentous material in the nuclei were mainly perivascular. In A-LD, some macrophages in active lesions contained similar nuclei, and in Kuf's disease they were present in some glial cells in the cerebral cortex.
对多发性硬化症（MS）斑块、肾上腺脑白质营养不良（A-LD）引起的炎症性中枢神经系统病变、一例慢性肉芽肿性脑膜炎的组织、坏死性脑皮质活检样本以及一例库夫病（成人型类蜡样脂褐质沉积症）的中枢神经系统组织进行的详细超微结构比较检查显示，先前认为与MS病毒感染有关的核内丝状物质是一种非特异性发现。然而，这些核内条索在MS急性病变中出现的频率最高，而在慢性脱髓鞘区域则不存在。细胞核中含有丝状物质的巨噬细胞、淋巴细胞和纤维细胞主要位于血管周围。在A-LD中，活跃病变中的一些巨噬细胞含有类似的细胞核，而在库夫病中，它们存在于大脑皮质的一些神经胶质细胞中。
