Le Uyen M, Cui Zhengrong
Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, 231 Pharmacy Building, Corvallis, OR 97331, USA.
Int J Pharm. 2006 Aug 31;320(1-2):96-103. doi: 10.1016/j.ijpharm.2006.04.009. Epub 2006 May 19.
To deliver and maintain a sufficient amount of Gd into tumors is required for a successful Gd neutron capture therapy (Gd-NCT), but it has been proven to be rather challenging to achieve. Previously, we have reported a Gd-encapsulated liposome formulation that has the potential to overcome this challenge. In the present study, we sought to systemically evaluate the biodistribution and the tumor-accumulation of the Gd in model tumor-bearing mice. The Gd-encapsulated liposomes were injected into mice pre-grafted with two different model tumors. The Gd content in the tumors and other organs were determined at various time after the injection. A sufficient amount of Gd was readily delivered into those two different model tumors. Increasing the dose of Gd by injecting the Gd-encapsulated liposomes multiple times tended to increase the uptake of the Gd by the tumors. Finally, the uptake of Gd by tumors was inversely correlated with the size of the tumors. The Gd-encapsulated liposomes hold great potentials as a Gd delivery system for NCT of small- and medium-size tumors. Alternative strategies may have to be adopted in order to use NCT to treat large, advanced solid tumors, although for which, Gd-NCT might be advantageous over boron-NCT.
成功的钆中子俘获疗法（Gd-NCT）需要向肿瘤输送并维持足够量的钆，但事实证明这颇具挑战性。此前，我们报道了一种钆包封脂质体制剂，它有潜力克服这一挑战。在本研究中，我们试图系统评估钆在荷瘤模型小鼠体内的生物分布和肿瘤蓄积情况。将钆包封脂质体注射到预先接种了两种不同模型肿瘤的小鼠体内。在注射后的不同时间测定肿瘤和其他器官中的钆含量。足够量的钆很容易输送到这两种不同的模型肿瘤中。通过多次注射钆包封脂质体增加钆剂量往往会增加肿瘤对钆的摄取。最后，肿瘤对钆的摄取与肿瘤大小呈负相关。钆包封脂质体作为用于中小尺寸肿瘤NCT的钆递送系统具有巨大潜力。为了使用NCT治疗大型晚期实体瘤，可能不得不采用其他策略，不过就此而言，Gd-NCT可能比硼中子俘获疗法（boron-NCT）更具优势。
