Lee F
J Neurosurg. 1975 Jul;43(1):65-8. doi: 10.3171/jns.1975.43.1.0065.
A retrospective survey of 41 patients with unbiopsied thalamic, pontine, and medullary tumors treated with radiation therapy demonstrated 30% to 40% 3-year survival, with seven long-term survivors. Eleven of the 12 patients surviving over 3 years have essentially normal neurological function. Of seven patients in whom histological diagnoses were eventually obtained, four proved to have glioblastomas and three low-grade astrocytomas. Autopsy revealed that all glioblastomatous tumors extended beyond the treatment field; this suggested that larger volumes, perhaps the whole brain, should be irradiated. High doses (at least 5000 rads) should be used since the 3-year survival among those receiving such doses was 45%.
一项对41例未经活检的丘脑、脑桥和延髓肿瘤患者进行放射治疗的回顾性调查显示，3年生存率为30%至40%，有7名长期存活者。12名存活超过3年的患者中有11名神经功能基本正常。在最终获得组织学诊断的7名患者中，4名被证实患有胶质母细胞瘤，3名患有低级别星形细胞瘤。尸检显示，所有胶质母细胞瘤性肿瘤均超出治疗野；这表明应照射更大的体积，可能是全脑。应使用高剂量（至少5000拉德），因为接受此类剂量的患者3年生存率为45%。
