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口腔矫治器与颌骨前徙手术:阻塞性睡眠呼吸暂停低通气综合征的一种替代治疗方案

Oral appliances and maxillomandibular advancement surgery: an alternative treatment protocol for the obstructive sleep apnea-hypopnea syndrome.

作者信息

Hoekema Aarnoud, de Lange Jan, Stegenga Boudewijn, de Bont Lambert G M

机构信息

Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

出版信息

J Oral Maxillofac Surg. 2006 Jun;64(6):886-91. doi: 10.1016/j.joms.2005.11.041.

Abstract

PURPOSE

The present study comprises a retrospective evaluation of the potential application of mandibular repositioning appliance (MRA) therapy preceding maxillomandibular advancement (MMA) surgery in the treatment of the Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). Our initial experiences with a new surgical protocol, in which MRA therapy serves as a predictor for success of MMA surgery, are reported.

PATIENTS AND METHODS

Forty-three consecutive patients with OSAHS treated with MRA therapy were considered for inclusion (mean+/-SD; Apnea-Hypopnea Index [AHI]=27+/-20; age=53+/-9 years). All patients displaying a substantial improvement in their AHI with MRA therapy (ie,>50% reduction) who preferred surgical rather than "prosthetic" advancement of the mandible were offered MMA surgery. Accordingly, 4 out of 43 patients were treated with MMA surgery. The AHI was used as the primary outcome measure, with MMA surgery being considered successful in case of a postoperative AHI <5.

RESULTS

All 4 patients included displayed substantial improvement in their AHI following MRA therapy. Moreover, in 3 patients MRA therapy resulted in a post-treatment AHI <or=5. With respect to the primary outcome measure, successful OSAHS management was attained in all 4 patients following MMA surgery.

CONCLUSION

Results from the 4 patients included in the present study suggest that MRA therapy might be a good predictor for the success of MMA surgery in OSAHS management. Although confirmation in a larger study sample is indicated, we conclude that patients with a substantial reduction in baseline AHI with MRA therapy appear to be candidates for MMA surgery.

摘要

目的

本研究包括对下颌重新定位矫治器(MRA)治疗在颌骨前移(MMA)手术治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)之前的潜在应用进行回顾性评估。报告了我们采用一种新的手术方案的初步经验,其中MRA治疗可作为MMA手术成功的预测指标。

患者与方法

连续纳入43例接受MRA治疗的OSAHS患者(均值±标准差;呼吸暂停低通气指数[AHI]=27±20;年龄=53±9岁)。所有经MRA治疗后AHI有显著改善(即降低>50%)且倾向于手术而非“假体”下颌前移的患者接受了MMA手术。因此,43例患者中有4例接受了MMA手术。AHI用作主要结局指标,术后AHI<5则认为MMA手术成功。

结果

纳入的4例患者经MRA治疗后AHI均有显著改善。此外,3例患者经MRA治疗后AHI≤5。就主要结局指标而言,4例患者接受MMA手术后OSAHS均得到成功治疗。

结论

本研究纳入的4例患者的结果表明,MRA治疗可能是OSAHS管理中MMA手术成功的良好预测指标。尽管需要更大样本的研究加以证实,但我们得出结论,经MRA治疗后基线AHI大幅降低的患者似乎是MMA手术的候选者。

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