Foglia Manzillo V, Restucci B, Pagano A, Gradoni L, Oliva G
Dipartimento di Scienze Cliniche Veterinarie, Sezione Clinica Medica, Facolta di Medicina Veterinarie, via F. Delpino 1, 80137 Naples, Italy.
Vet Rec. 2006 May 20;158(20):690-4. doi: 10.1136/vr.158.20.690.
Bone marrow aspiration smears from 15 dogs naturally infected with leishmania were evaluated. Three of the dogs showed no clinical signs, six had up to three clinical signs and six had more than three. The most common pathological features of the bone marrow were megakaryocytic dysplasia in 10 of the dogs, erythrophagocytosis in eight, erythroid dysplasia in two and emperipolesis in two. The megakaryocytic and erythroid dysplasia were probably related to an increased number of marrow macrophages producing high levels of tumour necrosis factor alpha and interferon gamma. Six of the dogs with clinical signs showed bone marrow dysplastic features and erythrophagocytosis, suggesting that leishmaniosis could be the unique cause of both conditions.
对15只自然感染利什曼原虫的犬的骨髓穿刺涂片进行了评估。其中3只犬无临床症状，6只犬有多达3种临床症状，6只犬有超过3种临床症状。骨髓最常见的病理特征为10只犬出现巨核细胞发育异常，8只出现红细胞吞噬现象，2只出现红系发育异常，2只出现血细胞入胞现象。巨核细胞和红系发育异常可能与产生高水平肿瘤坏死因子α和干扰素γ的骨髓巨噬细胞数量增加有关。6只出现临床症状的犬表现出骨髓发育异常特征和红细胞吞噬现象，提示利什曼病可能是这两种情况的唯一病因。
