Kornaat Peter R, Bloem Johan L, Ceulemans Ruth Y T, Riyazi Naghmeh, Rosendaal Frits R, Nelissen Rob G, Carter Wayne O, Hellio Le Graverand Marie-Pierre, Kloppenburg Margreet
Department of Radiology, Leiden University Medical Center, Albinusdreef 2, NL-2333 ZA Leiden, the Netherlands.
Radiology. 2006 Jun;239(3):811-7. doi: 10.1148/radiol.2393050253.
To prospectively evaluate the association between clinical features and structural abnormalities found at magnetic resonance (MR) imaging in patients with osteoarthritis (OA) of the knee.
The study was approved by the institutional medical ethics review board. Written informed consent was obtained from each patient. MR images of the knee were obtained from 205 (42 [20%] men, 163 [80%] women; median age, 60 years; range, 43-77 years) patients in whom symptomatic OA at multiple joint sites was diagnosed. MR images were analyzed for various abnormalities of OA. All patients were interviewed concerning pain and stiffness in the knee that was imaged. Odds ratios (ORs) with 99% confidence intervals (CIs) were used to determine the association between the imaging findings and clinical features of OA.
A large joint effusion was associated with pain (OR, 9.99; 99% CI: 1.28, 149) and stiffness (OR, 4.67; 99% CI: 1.26, 26.1). The presence of an osteophyte in the patellofemoral compartment (OR, 2.25; 99% CI: 1.06, 4.77) was associated with pain. All other imaging findings, including focal or diffuse cartilaginous abnormalities, subchondral cysts, bone marrow edema, subluxation of the meniscus, meniscal tears, or Baker cysts, were not associated with symptoms.
Findings of this study indicate that only two associations exist between clinical symptoms and structural findings found on MR images in patients with OA of the knee.
前瞻性评估膝关节骨关节炎（OA）患者磁共振（MR）成像发现的临床特征与结构异常之间的关联。
本研究经机构医学伦理审查委员会批准。获得了每位患者的书面知情同意书。对205例（42例[20%]男性，163例[80%]女性；中位年龄60岁；范围43 - 77岁）诊断为多关节部位有症状性OA的患者进行了膝关节MR成像检查。对MR图像分析OA的各种异常情况。就成像的膝关节的疼痛和僵硬情况对所有患者进行了访谈。使用具有99%置信区间（CI）的优势比（OR）来确定OA的成像结果与临床特征之间的关联。
大量关节积液与疼痛（OR，9.99；99% CI：1.28，149）和僵硬（OR，4.67；99% CI：1.26，26.1）相关。髌股关节间有骨赘（OR，2.25；99% CI：1.06，4.77）与疼痛相关。所有其他成像结果，包括局灶性或弥漫性软骨异常、软骨下囊肿、骨髓水肿、半月板半脱位、半月板撕裂或腘窝囊肿，均与症状无关。
本研究结果表明，膝关节OA患者的临床症状与MR图像上的结构发现之间仅存在两种关联。
