Rutter Guy A, Hill Elaine V
Department of Biochemistry, School of Medical Sciences, University Walk University of Bristol, Bristol, United Kingdom.
Physiology (Bethesda). 2006 Jun;21:189-96. doi: 10.1152/physiol.00002.2006.
The mechanisms by which insulin-containing dense core secretory vesicles approach and finally fuse with the plasma membrane are of considerable current interest: defects in these processes may be one of the contributing factors to Type 2 diabetes. In this review, we discuss the molecular mechanisms involved in vesicle trafficking within the pancreatic beta-cell and the mechanisms whereby these may be regulated. We then go on to describe recent evidence that suggests that vesicle fusion at the plasma membrane is a partly reversible process ("kiss and run" or "cavity recapture"). We propose that vesicles may participate in a exo-endocytotic cycle in which a proportion of those that have already undergone an interaction with the plasma membrane may exchange exocytotic machinery with maturing vesicles.
这些过程中的缺陷可能是2型糖尿病的促成因素之一。在这篇综述中，我们讨论了胰腺β细胞内囊泡运输所涉及的分子机制以及这些机制可能的调控方式。接着，我们继续描述最近的证据，这些证据表明质膜处的囊泡融合是一个部分可逆的过程（“亲吻后逃离”或“腔室重捕”）。我们提出囊泡可能参与一个外排 - 内吞循环，其中一部分已经与质膜发生相互作用的囊泡可能与成熟囊泡交换外排机制。
