Schifferli J, Leski M, Favre H, Imbach P, Nydegger U, Davies K
Division of Nephrology, Hôpital Cantonal Universitaire, Geneva, Switzerland.
Lancet. 1991 Feb 23;337(8739):457-8. doi: 10.1016/0140-6736(91)93395-p.
In an open trial of high dose intravenous IgG (IVIG) treatment in nephrotic patients with glomerulonephritis, the first six patients so far studied showed a transient rise in plasma creatinine. This increase was not associated with any symptoms and the urinary deposit remained unchanged. Two other patients with pre-existing renal impairment but without nephrotic syndrome had a transient and reversible rise in plasma creatinine immediately after IVIG. These observations suggest that high-dose IVIG infusion can produce short-lived disturbances in renal function in patients with kidney diseases.
