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In juvenile idiopathic arthritis, is folate supplementation effective against methotrexate toxicity at the expense of methotrexate's efficacy?在青少年特发性关节炎中，补充叶酸以牺牲甲氨蝶呤的疗效为代价来对抗其毒性是否有效？
Arch Dis Child. 2006 Jun;91(6):537-8. doi: 10.1136/adc.2006.094219.
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Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review.类风湿关节炎中的叶酸补充与甲氨蝶呤治疗：一项综述
Rheumatology (Oxford). 2004 Mar;43(3):267-71. doi: 10.1093/rheumatology/keh088. Epub 2004 Jan 6.
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[Reducing toxicity of methotrexate with folic acid].[用叶酸降低甲氨蝶呤的毒性]
Z Rheumatol. 2005 Jun;64(5):353-8. doi: 10.1007/s00393-005-0638-3.
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Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.在类风湿关节炎的长期低剂量甲氨蝶呤治疗期间，补充叶酸可预防血液叶酸水平不足和高同型半胱氨酸血症：对预防心血管疾病的意义。
J Rheumatol. 1998 Mar;25(3):441-6.
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Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation.类风湿关节炎中的高同型半胱氨酸血症：甲氨蝶呤治疗及补充叶酸的影响
J Rheumatol. 2002 Aug;29(8):1615-8.
6
High prevalence of methotrexate intolerance in juvenile idiopathic arthritis: development and validation of a methotrexate intolerance severity score.甲氨蝶呤不耐受在幼年特发性关节炎中高发：甲氨蝶呤不耐受严重程度评分的制定与验证
Arthritis Rheum. 2011 Jul;63(7):2007-13. doi: 10.1002/art.30367.
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Methotrexate in juvenile idiopathic arthritis: answers and questions.甲氨蝶呤治疗幼年特发性关节炎：答案与疑问
J Rheumatol. 2000 Aug;27(8):1830-3.
8
[Methotrexate treatment of rheumatoid arthritis].
Schweiz Med Wochenschr. 1996 Apr 27;126(17):703-12.
9
Hodgkin's disease in a patient with juvenile rheumatoid arthritis taking weekly low dose methotrexate.一名患有青少年类风湿关节炎且每周服用低剂量甲氨蝶呤的患者患霍奇金淋巴瘤。
J Rheumatol. 1998 Jun;25(6):1245-6.
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Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.叶酸和亚叶酸用于减轻类风湿关节炎患者接受甲氨蝶呤治疗时的副作用。
Cochrane Database Syst Rev. 2000(2):CD000951. doi: 10.1002/14651858.CD000951.

引用本文的文献

1
An Overview of Nutritional Aspects in Juvenile Idiopathic Arthritis.青少年特发性关节炎的营养方面概述。
Nutrients. 2022 Oct 20;14(20):4412. doi: 10.3390/nu14204412.
2
Folate usage in MTX-treated juvenile idiopathic arthritis (JIA) patients is inconsistent and highly variable.甲氨蝶呤治疗的幼年特发性关节炎（JIA）患者中叶酸的使用情况不一致且差异很大。
Rheumatol Int. 2013 Sep;33(9):2437-40. doi: 10.1007/s00296-013-2696-1. Epub 2013 Feb 12.
3
Nutritional supplementation and dietary restriction in the resolution of enthesitis-related arthritis.营养补充与饮食限制在附着点炎相关关节炎缓解中的作用
JRSM Short Rep. 2011 Apr 18;2(4):32. doi: 10.1258/shorts.2011.011012.

本文引用的文献

1
A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate.一项针对对标准剂量甲氨蝶呤无反应的幼年特发性关节炎患儿的随机试验，比较肠外给予甲氨蝶呤的中等剂量与高剂量。
Arthritis Rheum. 2004 Jul;50(7):2191-201. doi: 10.1002/art.20288.
2
Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. An update and proposals for guidelines.类风湿关节炎患者甲氨蝶呤治疗期间的叶酸补充。最新情况及指南建议。
Scand J Rheumatol. 2001;30(3):129-34. doi: 10.1080/030097401300162888.
3
Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study.叶酸或亚叶酸补充剂对甲氨蝶呤治疗类风湿关节炎的毒性和疗效的影响：一项为期48周的多中心、随机、双盲、安慰剂对照研究。
Arthritis Rheum. 2001 Jul;44(7):1515-24. doi: 10.1002/1529-0131(200107)44:7<1515::AID-ART273>3.0.CO;2-7.
4
Efficacy of folinic acid in reducing methotrexate toxicity in juvenile idiopathic arthritis.亚叶酸在降低幼年特发性关节炎中甲氨蝶呤毒性方面的疗效。
Clin Exp Rheumatol. 1999 Sep-Oct;17(5):625-7.
5
The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials.叶酸和亚叶酸在减轻类风湿关节炎中甲氨蝶呤胃肠道毒性方面的疗效：一项随机对照试验的荟萃分析。
J Rheumatol. 1998 Jan;25(1):36-43.
6
The effects of daily intake of folic acid on the efficacy of methotrexate therapy in children with juvenile rheumatoid arthritis. A controlled study.每日摄入叶酸对幼年类风湿关节炎患儿甲氨蝶呤治疗疗效的影响。一项对照研究。
J Rheumatol. 1997 Nov;24(11):2230-2.
7
Folinic acid supplementation in patients with juvenile rheumatoid arthritis treated with methotrexate.甲氨蝶呤治疗的青少年类风湿关节炎患者补充亚叶酸。
J Rheumatol. 1996 Feb;23(2):403-4.
8
Methotrexate in rheumatoid arthritis. Toxic effects as the major factor in limiting long-term treatment.类风湿关节炎中的甲氨蝶呤。毒性作用是限制长期治疗的主要因素。
Arthritis Rheum. 1989 Jun;32(6):671-6. doi: 10.1002/anr.1780320603.
9
The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis.补充叶酸对类风湿关节炎患者低剂量甲氨蝶呤毒性的影响。
Arthritis Rheum. 1990 Jan;33(1):9-18. doi: 10.1002/art.1780330102.
10
Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid.给予亚叶酸后接受甲氨蝶呤治疗的类风湿关节炎患者病情加重。
Ann Rheum Dis. 1991 Dec;50(12):913-4. doi: 10.1136/ard.50.12.913.

In juvenile idiopathic arthritis, is folate supplementation effective against methotrexate toxicity at the expense of methotrexate's efficacy?

作者信息

Killeen O G, Gardner-Medwin J M

机构信息

Paediatric Rheumatology, Department of Child Health, RHSC, Glasgow, UK.

出版信息

Arch Dis Child. 2006 Jun;91(6):537-8. doi: 10.1136/adc.2006.094219.

DOI:10.1136/adc.2006.094219
PMID:16714734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2082770/
Abstract
摘要