Joyce D A, Will R K, Hoffman D M, Laing B, Blackbourn S J
Department of Pharmacology, University of Western Australia, Nedlands.
Ann Rheum Dis. 1991 Dec;50(12):913-4. doi: 10.1136/ard.50.12.913.
A double blind, placebo controlled trial examined the effects of folinic acid on the efficacy and toxicity of methotrexate in 27 patients with rheumatoid arthritis. Clinical and laboratory indices of disease activity worsened significantly in the 13 patients treated with folinic acid after four weeks of treatment, but not in the 14 patients treated with placebo. Exacerbation of rheumatoid arthritis led to withdrawal of the test drug in seven of the patients treated with folinic acid but in none of those treated with placebo. It is concluded that excerbation of rheumatoid arthritis is likely when folinic acid is given shortly after the weekly dose of methotrexate.
一项双盲、安慰剂对照试验研究了亚叶酸对27例类风湿性关节炎患者甲氨蝶呤疗效和毒性的影响。治疗四周后，接受亚叶酸治疗的13例患者的疾病活动临床和实验室指标显著恶化，而接受安慰剂治疗的14例患者则未出现这种情况。类风湿性关节炎病情加重导致7例接受亚叶酸治疗的患者停用试验药物，而接受安慰剂治疗的患者中无人出现这种情况。得出的结论是，在每周服用甲氨蝶呤后不久给予亚叶酸，可能会使类风湿性关节炎病情加重。
