Mohadjer Yasaman, Holds John B, Rootman Jack, Wilson Mathew W, Gigantelli James W, Custer Philip L
Department of Ophthalmology, Saint Louis University, MO 63141, USA,
Ophthalmic Plast Reconstr Surg. 2006 May-Jun;22(3):163-8. doi: 10.1097/01.iop.0000217563.00975.a3.
To describe the spectrum and treatment of orbital Rosai-Dorfman disease and to review previously documented cases.
Retrospective, interventional case series of seven patients and literature review.
Each patient with Rosai-Dorfman disease had unique disease expression requiring aggressive therapy, such as chemotherapy, radiation, and/or surgical excision. One systemically aggressive case presented with intraocular and choroidal invasion, a previously unreported finding. Response to therapy was variable and unpredictable.
Rosai-Dorfman disease, although historically described as benign and self-limiting, may cause significant morbidity and mortality involving multiple organ systems. Available treatment options may not control the disease. Further research and long-term clinical correlation is necessary.
描述眼眶罗萨伊-多夫曼病的谱系及治疗方法，并回顾既往记录的病例。
对7例患者进行回顾性、干预性病例系列研究及文献综述。
每例罗萨伊-多夫曼病患者都有独特的疾病表现，需要积极治疗，如化疗、放疗和/或手术切除。1例具有全身侵袭性的病例出现了眼内及脉络膜侵犯，这是一个此前未报告过的发现。治疗反应各不相同且不可预测。
罗萨伊-多夫曼病尽管在历史上被描述为良性且自限性疾病，但可能导致涉及多个器官系统的显著发病率和死亡率。现有的治疗选择可能无法控制该病。有必要进行进一步研究和长期临床关联研究。
