Brem M H, Schlechtweg P M, Mackenzie J, Winalski C S, Lang P
Department of Radiology, Brigham and Women's Hospital of Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Radiologe. 2006 May;46(5):394-402. doi: 10.1007/s00117-006-1373-8.
Molecular imaging is an upcoming field in radiology as a result of great advances in imaging technology, genetics, and biochemistry in the recent past. Early-stage imaging of molecular pathological changes in cells opens the gates to new methods in medical treatment of diseases that otherwise would only be detected in advanced stages. Methods of imaging biochemical pathways with molecular agents are currently an issue of intensive research. This article reviews current modalities of molecular imaging in arthritis that should offer future perspective on early disease detection, diagnosis, and monitoring of treatment efficiency and how they can pave the way to optimized therapy.
由于近年来成像技术、遗传学和生物化学领域取得了巨大进展，分子成像已成为放射学中一个新兴的领域。对细胞分子病理变化进行早期成像，为疾病医疗新方法打开了大门，否则这些疾病只有在晚期才能被检测到。利用分子试剂对生化途径进行成像的方法目前是深入研究的课题。本文综述了关节炎分子成像的当前模式，这些模式应为疾病早期检测、诊断以及治疗效果监测提供未来前景，以及它们如何为优化治疗铺平道路。
