Higuchi Ryota, Yamamoto Masakazu, Hatori Takashi, Shimizu Koichi, Imai Kenichirou, Takasaki Ken
Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan.
Surg Today. 2006;36(6):559-62. doi: 10.1007/s00595-006-3201-1.
Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis. However, we treated ICC with LN metastasis successfully by surgery and postoperative immunotherapy in a 59-year-old woman. The immunotherapy consisted of CD3-activated T cells and tumor lysate- or peptide-pulsed dendritic cells. Pathological examination confirmed a diagnosis of moderately differentiated adenocarcinoma with LN metastasis and portal vein invasion. The patient has been alive without recurrence for 3 years 6 months since her operation.
伴有淋巴结转移的肝内胆管癌（ICC）通常预后较差。然而，我们成功地对一名59岁女性的伴有淋巴结转移的ICC患者进行了手术及术后免疫治疗。免疫治疗包括CD3激活的T细胞和肿瘤裂解物或肽脉冲树突状细胞。病理检查确诊为中度分化腺癌伴淋巴结转移和门静脉侵犯。该患者自手术以来已存活3年6个月，无复发。
