Ergün Eser Lay, Salanci Bilge Volkan, Erbaş Belkis, Saygi Serap
Department of Nuclear Medicine, School of Medicine, Hacettepe University, 06100 Sihhiye, Ankara, Turkey.
Ann Nucl Med. 2006 Apr;20(3):227-31. doi: 10.1007/BF03027435.
Periodic lateralized epileptiform discharges (PLEDs), which are known as unusual electroencephalogram (EEG) patterns, are described in a patient who had stroke and seizures. This patient underwent Tc-99m HMPAO (hexamethyl propylene amine oxime) brain single photon emission computed tomography (SPECT) imaging both during PLEDs on EEG and after the cessation of PLEDs. The initial SPECT study revealed increased CBF in the left frontal and parietal cortex extending through the left temporal region and in the left basal ganglium. After the PLEDs disappeared, the second SPECT study showed decreased perfusion on the left frontal and parietal region in the brain. Brain SPECT findings supported the contention that PLEDs may be an ictal phenomenon. Here we also present a review on PLEDs and contributions of brain SPECT as a functional imaging modality to investigate the underlying mechanism of this interesting EEG pattern.
周期性一侧性癫痫样放电（PLEDs）是一种不常见的脑电图（EEG）模式，在一名患有中风和癫痫的患者中被描述。该患者在脑电图上出现PLEDs期间以及PLEDs停止后均接受了锝-99m六甲基丙烯胺肟（HMPAO）脑单光子发射计算机断层扫描（SPECT）成像。最初的SPECT研究显示，左侧额叶和顶叶皮质的脑血流量增加，延伸至左侧颞叶区域以及左侧基底神经节。PLEDs消失后，第二次SPECT研究显示大脑左侧额叶和顶叶区域的灌注减少。脑SPECT结果支持了PLEDs可能是一种发作期现象的观点。在此，我们还对PLEDs以及脑SPECT作为一种功能成像方式在研究这种有趣的脑电图模式潜在机制方面的作用进行了综述。
