Tilley Douglas G, Rockman Howard A
Department of Medicine Duke University Medical Center Durham, NC 27710, USA.
Expert Rev Cardiovasc Ther. 2006 May;4(3):417-32. doi: 10.1586/14779072.4.3.417.
The use of beta-blockers to antagonize beta-adrenergic receptor signaling in the heart has become a standard method of treatment for heart failure, resulting in positive clinical outcomes alone and in conjunction with other modulators of cardiomyocyte contractility. However, an entire explanation for improved cardiac function in patients using beta-blockers is unknown, and in fact may be quite complicated, considering the numerous intracellular signaling pathways associated with beta-adrenergic receptors. Stimulation of beta-adrenergic receptors during both normal conditions and during heart failure activate several distinct signaling cascades, which influence cardiomyocyte contraction, hypertrophy and apoptosis. This review explores the signaling cascades induced by beta-adrenergic receptor activation in normal and desensitized states to provide new insight into the effective treatment of cardiac dysfunction.
使用β受体阻滞剂拮抗心脏中的β肾上腺素能受体信号传导已成为治疗心力衰竭的标准方法，单独使用以及与其他心肌收缩力调节剂联合使用时均能产生积极的临床效果。然而，对于使用β受体阻滞剂的患者心脏功能改善的完整解释尚不清楚，而且考虑到与β肾上腺素能受体相关的众多细胞内信号通路，其实际情况可能相当复杂。在正常状态和心力衰竭期间，β肾上腺素能受体的刺激都会激活几个不同的信号级联反应，这些反应会影响心肌细胞的收缩、肥大和凋亡。本综述探讨了在正常和脱敏状态下由β肾上腺素能受体激活诱导的信号级联反应，以便为心脏功能障碍的有效治疗提供新的见解。
