Landre Nancy, Poppe Christopher J, Davis Nancy, Schmaus Brian, Hobbs Susan E
Neuropsychology Service, Parkside Building, Suite 690, Advocate Lutheran General Hospital, 1775 Dempster Street, Park Ridge, IL 60068, United States.
Arch Clin Neuropsychol. 2006 May;21(4):255-73. doi: 10.1016/j.acn.2005.12.007. Epub 2006 May 22.
Although there is a large body of research on mild traumatic brain injury (MTBI), the portion that pertains to acute patients (those less than 1 month postinjury) is relatively small and yields inconsistent findings. The potential contribution of non-neurological factors, such as pain and emotional distress, to the clinical picture in this population is also lacking. To address these issues, the cognitive performance and symptom complaints of 37 hospitalized MTBI subjects were compared to those of 39 hospitalized trauma subjects, averaging 4.5 days postinjury. MTBI subjects performed significantly worse on all cognitive measures, but did not differ from trauma subjects in their report of postconcussive symptoms. Analyses also revealed that cognitive performance was unrelated to pain severity and emotional distress. Postconcussive symptoms were similarly unrelated to pain severity, but were consistently related to emotional distress. Results are discussed in terms of their etiological and treatment implications.
尽管有大量关于轻度创伤性脑损伤（MTBI）的研究，但涉及急性患者（受伤后不到1个月的患者）的部分相对较少，且结果并不一致。该人群中疼痛和情绪困扰等非神经因素对临床表现的潜在影响也尚不明确。为解决这些问题，研究人员将37名住院的MTBI患者与39名住院的创伤患者（平均受伤后4.5天）的认知表现和症状主诉进行了比较。MTBI患者在所有认知测试中的表现明显更差，但在脑震荡后症状报告方面与创伤患者没有差异。分析还显示，认知表现与疼痛严重程度和情绪困扰无关。脑震荡后症状同样与疼痛严重程度无关，但与情绪困扰始终相关。研究结果将从病因学和治疗意义方面进行讨论。
