Slagsvold Thomas, Pattni Krupa, Malerød Lene, Stenmark Harald
Department of Biochemistry, the Norwegian Radium Hospital and the University of Oslo, Montebello, N-0310 Oslo, Norway.
Trends Cell Biol. 2006 Jun;16(6):317-26. doi: 10.1016/j.tcb.2006.04.004. Epub 2006 May 22.
The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that have shed light on the mechanisms by which these complexes mediate protein sorting, MVB biogenesis, tumour suppression and viral budding. We also discuss evidence that some ESCRT subunits have evolved additional functions that are unrelated to membrane trafficking.
三种运输所需的内体分选复合物（ESCRT）对于内吞膜蛋白的降解和多泡体（MVB）的生物发生至关重要。在此，我们综述了相关证据，表明ESCRT已演变成一种用于泛素化膜蛋白降解分选的特殊机制，并且我们着重介绍了最近的一些研究，这些研究揭示了这些复合物介导蛋白质分选、MVB生物发生、肿瘤抑制和病毒出芽的机制。我们还讨论了一些证据，表明某些ESCRT亚基已经进化出与膜运输无关的其他功能。
