Babst Markus
University of Utah, Department of Biology, 257 South 1400 East Salt Lake City, UT 84112, USA.
Traffic. 2005 Jan;6(1):2-9. doi: 10.1111/j.1600-0854.2004.00246.x.
In eukaryotic cells, delivery of transmembrane proteins into the lumen of the lysosome for degradation is mediated by the multivesicular body pathway. The function of the ESCRT protein complexes is required for both the formation of multivesicular body lumenal vesicles and the sorting of endosomal cargo proteins into these vesicles. Recent studies have identified additional factors that seem to function as an upstream cargo retention system feeding into the ESCRT machinery, given new insights into the dynamic structure of multivesicular bodies, and identified a potential mechanism for multivesicular body vesicle formation.
在真核细胞中，跨膜蛋白被递送至溶酶体腔进行降解是由多泡体途径介导的。内体分选转运复合体（ESCRT）蛋白复合物的功能对于多泡体腔泡的形成以及将内体货物蛋白分选到这些泡中都是必需的。最近的研究已经确定了其他一些似乎作为上游货物保留系统发挥作用的因子，这些因子为多泡体的动态结构提供了新的见解，并确定了多泡体泡形成的潜在机制，该系统将信息输入到ESCRT机制中。
