Monton Maria Rowena N, Terabe Shigeru
Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0017, Japan.
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Sep 1;841(1-2):88-95. doi: 10.1016/j.jchromb.2006.04.017. Epub 2006 May 22.
Compared to chromatography-based techniques, the concentration limits of detection (CLOD) associated with capillary electrophoresis are worse, and these have largely precluded their use in many practical applications. To overcome this limitation, researchers from various disciplines have exerted tremendous efforts toward developing strategies for increasing the concentration sensitivities of capillary electrophoresis (CE) systems, via the so-called sample enrichment techniques. This review highlights selected developments and advances in this area as applied to the analyses of proteins and peptides in the last 5 years.
与基于色谱的技术相比，毛细管电泳的检测浓度限（CLOD）更差，这在很大程度上限制了其在许多实际应用中的使用。为了克服这一限制，来自各个学科的研究人员付出了巨大努力，通过所谓的样品富集技术来开发提高毛细管电泳（CE）系统浓度灵敏度的策略。本综述重点介绍了过去5年中该领域在蛋白质和肽分析方面的一些选定进展。
