Naeimi Zahra S, Weinhofer Alexandra, Sarahrudi Kambiz, Heinz Thomas, Vécsei Vilmos
Department of Traumatology, Medical University Vienna, Austria.
Brain Inj. 2006 May;20(5):463-8. doi: 10.1080/02699050600664418.
S-100B and NSE proteins are considered to be neurobiochemical markers for the brain damage. The aim of this study was to consider the diagnostic and prognostic validity of the initial serum levels of S-100B and NSE in clinical use.
Forty-five patients with traumatic brain injury were included in this prospective study. Neurologic examination and CCT-scan were performed. S-100B and NSE were analysed. Patients were divided in two groups depending on the severity of injury.
The results showed a significant difference between the S-100B serum concentration and the two groups-minor head injuries and severe head injuries. A statistically significant correlation was observed between an increase of S-100B and NSE serum values and a cerebral pathological finding in CT scans.
The clear correlation between S-100B and NSE serum concentrations and CCT findings does not validate both markers as an independent predictor of diagnosis and prognosis of brain injury.
S-100B和NSE蛋白被认为是脑损伤的神经生化标志物。本研究的目的是探讨S-100B和NSE初始血清水平在临床应用中的诊断和预后有效性。
本前瞻性研究纳入了45例创伤性脑损伤患者。进行了神经学检查和头颅CT扫描。分析了S-100B和NSE。根据损伤严重程度将患者分为两组。
结果显示，S-100B血清浓度在轻度颅脑损伤和重度颅脑损伤两组之间存在显著差异。S-100B和NSE血清值的升高与CT扫描中的脑部病理发现之间存在统计学显著相关性。
S-100B和NSE血清浓度与头颅CT检查结果之间的明确相关性并不能证实这两种标志物可作为脑损伤诊断和预后的独立预测指标。
