Katagiri Fumihiko, Shiga Toru, Inoue Shin, Sato Yuhki, Itoh Hiroki, Takeyama Masaharu
Department of Clinical Pharmacy, Oita University Hospital, Hasama-machi, Oita, Japan.
Pharmacology. 2006;77(3):115-21. doi: 10.1159/000093485. Epub 2006 May 22.
Itopride hydrochloride (itopride), a gastrokinetic drug, has recently been evaluated for its clinical usefulness in functional dyspepsia. We investigated effects of itopride on human plasma gastrin-, somatostatin-, motilin-, and cholecystokinin (CCK)-like immunoreactive substances (IS); adrenocorticotropic hormone (ACTH)-immunoreactive substances (IS), and cortisol under stress conditions in healthy subjects. A single administration of itopride caused significant increases in plasma somatostatin- and motilin-IS levels compared to placebo. Itopride significantly decreased plasma CCK-IS, and suppressed the ACTH-IS level compared to placebo. We hypothesize that itopride may have an accelerating gastric emptying effect, and a modulatory effect on the hypothalamo-pituitary-adrenal axis and autonomic nervous functions. These effects might be beneficial in stress-related diseases, suggesting that itopride has clinicopharmacological activities.
盐酸伊托必利（伊托必利）是一种胃肠动力药物，最近已对其在功能性消化不良中的临床效用进行了评估。我们研究了伊托必利对健康受试者在应激条件下的人血浆胃泌素、生长抑素、胃动素和胆囊收缩素（CCK）样免疫反应物质（IS）；促肾上腺皮质激素（ACTH）免疫反应物质（IS）以及皮质醇的影响。与安慰剂相比，单次给予伊托必利可使血浆生长抑素和胃动素-IS水平显著升高。与安慰剂相比，伊托必利可显著降低血浆CCK-IS，并抑制ACTH-IS水平。我们推测伊托必利可能具有加速胃排空的作用，以及对下丘脑-垂体-肾上腺轴和自主神经功能的调节作用。这些作用可能对应激相关疾病有益，提示伊托必利具有临床药理学活性。
