Amro Abdulaziz Nabil, Emran Khadijah, Alanazi Hessah
Department of Chemistry, College of Science, Taibah University, Madinah Saudi Arabia.
Department of Chemistry, College of Science and Art, Al Jouf University, Qurayyat Saudi Arabia.
Turk J Chem. 2020 Aug 18;44(4):1122-1133. doi: 10.3906/kim-2003-56. eCollection 2020.
In the present work TiO nanotubes (TNT) have been synthesized by alkaline hydrothermal transformation. Then they have been doped with Gd element. Characterizations of doped and undoped TNT have been done with TEM and SEM. The chemical composition was analyzed by EDX, Raman and FTIR spectroscopy. The crystal structure was characterized by XRD. Carbon paste electrode has been fabricated and mixed with Gd doped and undoped TNT to form a nanocomposite working electrode. Comparison of bare carbon paste electrode and Gd doped and undoped TNT carbon paste electrode for 1.0 ×10 M K [Fe(CN)] voltammetric analysis; it was observed that Gd doped TNT modified electrode has advantage of high sensitivity. Gd doped TNT modified electrode has been used as working electrode for itopride assay in a pharmaceutical formulation. Cyclic voltammetry analysis showed high correlation coefficient of 0.9973 for itopride (0.04-0.2 mg/mL) with a limit of detection (LOD) and limit of quantitation values (LOQ) of 2.9 and 23.0 μg.mL respectively.
在本工作中，通过碱性水热转化合成了TiO纳米管（TNT）。然后对其进行了Gd元素掺杂。利用透射电子显微镜（TEM）和扫描电子显微镜（SEM）对掺杂和未掺杂的TNT进行了表征。通过能量色散X射线光谱（EDX）、拉曼光谱和傅里叶变换红外光谱（FTIR）分析了化学成分。用X射线衍射（XRD）对晶体结构进行了表征。制备了碳糊电极，并将其与掺杂和未掺杂Gd的TNT混合，形成纳米复合工作电极。对裸碳糊电极以及掺杂和未掺杂Gd的TNT碳糊电极进行1.0×10 M K[Fe(CN)]的伏安分析；观察到掺杂Gd的TNT修饰电极具有高灵敏度的优势。掺杂Gd的TNT修饰电极已被用作药物制剂中伊托必利测定的工作电极。循环伏安分析表明，伊托必利（0.04 - 0.2 mg/mL）的相关系数高达0.9973，检测限（LOD）和定量限（LOQ）分别为2.9和23.0 μg/mL。
