Gupta Sandeep K, Hassall Eric, Chiu Yi-Lin, Amer Fouad, Heyman Melvin B
Riley Hospital for Children, 702 Barnhill Dr, Room ROC 4210, Indianapolis, IN 46202, USA.
Dig Dis Sci. 2006 May;51(5):858-63. doi: 10.1007/s10620-006-9095-3. Epub 2006 May 23.
Children and adolescents with symptomatic gastroesophageal reflux disease (GERD) and erosive esophagitis (EE) of grade >/=2 (n=45) or nonerosive esophagitis (NEE) (n=45) were assessed to determine the relationship between presenting symptoms, esophagitis severity, and patient age. Overall, regurgitation/vomiting, abdominal pain, and cough were the most frequent symptoms. The prevalence and severity of anorexia/feed refusal was significantly greater in EE versus NEE children; this symptom was also significantly more prevalent in younger (1-5 years) children (both NEE and EE groups) compared to older children. Cough was significantly less severe in NEE adolescents than in younger children. Cough, anorexia/feed refusal, and regurgitation/vomiting were more severe and heartburn was less severe in EE children aged 1-5 years compared with older patients. In conclusion, GERD in children manifests differently than that in adults and symptoms vary with patient age. Symptoms were not predictive of presence or lack of mucosal damage.
对患有症状性胃食管反流病（GERD）且食管炎分级大于或等于2级的侵蚀性食管炎（EE）患儿及青少年（n = 45）或非侵蚀性食管炎（NEE）患儿及青少年（n = 45）进行评估，以确定所表现出的症状、食管炎严重程度与患者年龄之间的关系。总体而言，反流/呕吐、腹痛和咳嗽是最常见的症状。与NEE患儿相比，EE患儿厌食/拒食的发生率和严重程度显著更高；与年龄较大的儿童相比，该症状在年龄较小（1至5岁）的儿童（NEE组和EE组）中也明显更为普遍。NEE青少年的咳嗽严重程度明显低于年龄较小的儿童。与年龄较大的患者相比，1至5岁的EE患儿咳嗽、厌食/拒食和反流/呕吐更为严重，而烧心症状则较轻。总之，儿童GERD的表现与成人不同，症状因患者年龄而异。症状不能预测黏膜损伤的存在与否。
