Knight Sarah L, Susser Judith, Greenwell Tamsin, Mundy Anthony R, Craggs Michael D
Institute of Urology, Royal Free & University College Medical School, London, UK.
Eur Urol. 2006 Sep;50(3):574-80. doi: 10.1016/j.eururo.2006.03.065. Epub 2006 May 2.
To perform a preliminary clinical investigation to determine the safety and efficacy of a novel artificial urinary sphincter (AUS) with conditional occlusion for the treatment of stress urinary incontinence.
Male patients with urodynamically proven stress urinary incontinence after a prostatectomy were implanted with the novel AUS. They were followed up over a period of 12 months and the device tested for efficacy by using objective measurements of urinary leakage and continence. We derived a new measure for continence called the Continence Index.
We have demonstrated that the patients receiving the new AUS showed a reduction of greater than 10-fold in mean daily leakage volume from 770.6 ml to 55.1 ml. There was an overall improvement in the Continence Index from 54% to 97%.
The new AUS with conditional occlusion provides good continence rates and enables adjustment of regulating pressure in situ.
进行一项初步临床研究，以确定一种新型有条件闭塞人工尿道括约肌（AUS）治疗压力性尿失禁的安全性和有效性。
前列腺切除术后经尿动力学证实为压力性尿失禁的男性患者植入新型AUS。对他们进行了为期12个月的随访，并通过对尿失禁和控尿的客观测量来测试该装置的有效性。我们得出了一种新的控尿测量方法，称为控尿指数。
我们已证明，接受新型AUS的患者平均每日漏尿量从770.6毫升降至55.1毫升，减少了10倍以上。控尿指数总体上从54%提高到了97%。
新型有条件闭塞AUS提供了良好的控尿率，并能够在原位调节调节压力。
