Maggi Stefania, Noale Marianna, Gallina Pietro, Bianchi Daniele, Marzari Chiara, Limongi Federica, Crepaldi Gaetano
National Research Council, Aging Branch, Institute of Neuroscience, Padova, Italy.
J Gerontol A Biol Sci Med Sci. 2006 May;61(5):505-10. doi: 10.1093/gerona/61.5.505.
The metabolic syndrome (MetS) is represented by a cluster of risk factors for cardiovascular diseases (CVDs). In spite of its high frequency and strong association with morbidity and mortality in the adult population, little is known about its magnitude in elderly persons.
We assessed the prevalence of MetS by diabetic status and sex in the participants in the Italian Longitudinal Study on Aging (ILSA), a population-based study on a sample of 5632 individuals 65-84 years old at baseline (1992). We measured the association of MetS with stroke, coronary heart disease, and diabetes at baseline and with CVD mortality at 4-year follow-up.
The prevalence of MetS was 25.9% in nondiabetic men and 55.2% in nondiabetic women; in diabetic individuals it was 64.9% and 87.1% in men and women, respectively. At baseline, in both men and women there was a significant association with stroke (odds ratio [OR]=1.67, 95% confidence interval [CI], 1.02-2.75 in men and OR=1.72, CI, 1.01-2.93 in women) and diabetes (OR=4.58, CI, 3.12-6.74 in men and OR=5.15, CI, 3.23-8.20 in women). A significant association with chronic heart disease was found in men only (OR=1.40; CI, 1.02-1.97). During the approximately 4-year follow-up, nondiabetic men with MetS had a risk of CVD mortality 12% higher compared to those without MetS, whereas no significant differences were found in women.
MetS is very common in aged Italians, and it is associated with stroke and diabetes in both sexes, and with chronic heart disease in men. In men, it increases significantly the risk of CVD mortality.
代谢综合征（MetS）表现为一系列心血管疾病（CVDs）的危险因素。尽管其在成年人群中发病率高且与发病和死亡密切相关，但对于老年人群中的患病程度却知之甚少。
我们在意大利纵向衰老研究（ILSA）的参与者中，按糖尿病状态和性别评估了MetS的患病率。ILSA是一项基于人群的研究，基线（1992年）样本为5632名65 - 84岁的个体。我们测量了基线时MetS与中风、冠心病和糖尿病的关联，以及4年随访时与CVD死亡率的关联。
非糖尿病男性中MetS的患病率为25.9%，非糖尿病女性中为55.2%；在糖尿病个体中，男性和女性分别为64.9%和87.1%。在基线时，男性和女性中MetS均与中风（男性优势比[OR]=1.67，95%置信区间[CI]为1.02 - 2.75；女性OR=1.72，CI为1.01 - 2.93）和糖尿病（男性OR=4.58，CI为3.12 - 6.74；女性OR=5.15，CI为3.23 - 8.20）存在显著关联。仅在男性中发现与慢性心脏病存在显著关联（OR=1.40；CI为1.02 - 1.97）。在大约4年的随访期间，患有MetS的非糖尿病男性CVD死亡风险比未患MetS的男性高12%，而女性中未发现显著差异。
MetS在老年意大利人中非常常见，它与男女的中风和糖尿病相关，在男性中与慢性心脏病相关。在男性中，它显著增加了CVD死亡风险。
