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在中国老年人中，体重指数与2型糖尿病有关。

Body mass index is associated with type 2 diabetes mellitus in Chinese elderly.

作者信息

Zhao Qianping, Laukkanen Jari A, Li Qifu, Li Gang

机构信息

Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

出版信息

Clin Interv Aging. 2017 May 2;12:745-752. doi: 10.2147/CIA.S130014. eCollection 2017.

DOI:10.2147/CIA.S130014
PMID:28496312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5422331/
Abstract

BACKGROUND

There is limited information on the association between metabolic syndrome components including body mass index (BMI) and type 2 diabetes mellitus in elderly Chinese population. Therefore, we investigated whether components of metabolic syndrome are associated with type 2 diabetes mellitus in elderly.

METHODS

A total of 479 hospitalized patients (aged 65-95 years) with recently diagnosed type 2 diabetes mellitus were studied retrospectively in a cross-sectional study and compared with 183 subjects with prediabetes and 62 subjects without glucose metabolism abnormalities.

RESULTS

BMI (24.69±3.59 versus 23.92±3.08 and 23.56±3.25 kg/m), blood pressure, cholesterol, triglyceride, liver enzymes and prevalence of fatty liver were higher in patients with type 2 diabetes mellitus as compared with elderly subjects with prediabetes or normal glucose metabolism separately (all <0.05). Multivariable regression analysis showed that BMI was associated positively with insulin resistance and inversely with insulin sensitivity in type 2 diabetes mellitus group (all <0.05).

CONCLUSION

Higher BMI was associated with increased insulin resistance and decreased insulin sensitivity in elderly Asian population with type 2 diabetes mellitus.

摘要

背景

关于包括体重指数（BMI）在内的代谢综合征各组分与中国老年人群2型糖尿病之间关联的信息有限。因此，我们调查了代谢综合征各组分是否与老年人的2型糖尿病相关。

方法

在一项横断面研究中，对479例近期诊断为2型糖尿病的住院患者（年龄65 - 95岁）进行回顾性研究，并与183例糖尿病前期患者和62例无糖代谢异常的受试者进行比较。

结果

与糖尿病前期或糖代谢正常的老年受试者相比，2型糖尿病患者的BMI（24.69±3.59 vs 23.92±3.08和23.56±3.25kg/m）、血压、胆固醇、甘油三酯、肝酶及脂肪肝患病率均更高（均P<0.05）。多变量回归分析显示，在2型糖尿病组中，BMI与胰岛素抵抗呈正相关，与胰岛素敏感性呈负相关（均P<0.05）。

结论

在患有2型糖尿病的亚洲老年人群中，较高的BMI与胰岛素抵抗增加及胰岛素敏感性降低相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/a9bf2fb1e1dd/cia-12-745Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/136d2900868c/cia-12-745Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/a4911ec6fd96/cia-12-745Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/5d66e514afa2/cia-12-745Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/65a7e8610f9b/cia-12-745Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/a9bf2fb1e1dd/cia-12-745Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/136d2900868c/cia-12-745Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/a4911ec6fd96/cia-12-745Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/5d66e514afa2/cia-12-745Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/65a7e8610f9b/cia-12-745Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3422/5422331/a9bf2fb1e1dd/cia-12-745Fig5.jpg

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