Ahlmann E R, Menendez L R, Kermani C, Gotha H
University of Southern California, Los Angeles, USA.
J Bone Joint Surg Br. 2006 Jun;88(6):790-5. doi: 10.1302/0301-620X.88B6.17519.
We reviewed retrospectively the results in 211 consecutive patients who had undergone limb salvage for bone neoplasia with endoprosthetic reconstruction of the proximal femur (96), distal femur (78), proximal tibia (30) and total femur (7). Their mean age was 50 years (11 to 86) and the mean follow-up period was 37.3 months (1 to 204). A total of 35 (16.6%) prostheses failed. Overall, implant survival was 78% (95% confidence interval (CI) 0.29 to 0.54) at five years, 60% (95% CI 0.93 to 2.35) at ten years and 60% (95% CI 1.27 to 3.88) at 15 years. Survivorship of the limb was 97.6% (95% CI 1.73 to 3.35) at ten years. The gender, age, diagnosis and location of the tumour were not prognostic variables for failure. Modular endoprosthetic replacement in the lower limb is a durable long-term reconstructive option, with the implants generally outlasting the patient.
我们回顾性分析了211例因骨肿瘤接受保肢手术并采用股骨近端（96例）、股骨远端（78例）、胫骨近端（30例）和全股骨（7例）假体置换重建的连续患者的结果。他们的平均年龄为50岁（11至86岁），平均随访期为37.3个月（1至204个月）。共有35例（16.6%）假体失败。总体而言，五年时植入物生存率为78%（95%置信区间（CI）0.29至0.54），十年时为60%（95%CI 0.93至2.35），十五年时为60%（95%CI 1.27至3.88）。十年时肢体生存率为97.6%（95%CI 1.73至3.35）。肿瘤的性别、年龄、诊断和部位不是失败的预后变量。下肢模块化假体置换是一种持久的长期重建选择，植入物通常比患者寿命长。
