Rosato Ezio, Tauber Eran, Kyriacou Charalambos P
Department of Genetics, University of Leicester, Leicester, UK.
Eur J Hum Genet. 2006 Jun;14(6):729-38. doi: 10.1038/sj.ejhg.5201547.
The circadian clock percolates through every aspect of behaviour and physiology, and has wide implications for human and animal health. The molecular basis of the Drosophila circadian clock provides a model system that has remarkable similarities to that of mammals. The various cardinal clock molecules in the fly are outlined, and compared to those of their actual and 'functional' homologues in the mammal. We also focus on the evolutionary tinkering of these clock genes and compare and contrast the neuronal basis for behavioural rhythms between the two phyla.
生物钟渗透到行为和生理的各个方面，对人类和动物健康具有广泛影响。果蝇生物钟的分子基础提供了一个与哺乳动物生物钟具有显著相似性的模型系统。本文概述了果蝇中各种主要的生物钟分子，并将其与哺乳动物中实际的和“功能”上的同源分子进行了比较。我们还着重探讨了这些生物钟基因的进化微调，并比较和对比了两个门类之间行为节律的神经基础。
