National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, United States; Interdisciplinary Program in Neuroscience, Georgetown University, Washington DC, United States; College of Medicine, University of Kentucky, Lexington, KY, United States.
National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Bethesda, MD, United States.
Mech Ageing Dev. 2023 Jul;213:111839. doi: 10.1016/j.mad.2023.111839. Epub 2023 Jun 23.
What is the nature of aging, and how best can we study it? Here, using a series of questions that highlight differing perspectives about the nature of aging, we ask how data from Drosophila melanogaster at the organismal, tissue, cellular, and molecular levels shed light on the complex interactions among the phenotypes associated with aging. Should aging be viewed as an individual's increasing probability of mortality over time or as a progression of physiological states? Are all age-correlated changes in physiology detrimental to vigor or are some compensatory changes that maintain vigor? Why do different age-correlated functions seem to change at different rates in a single individual as it ages? Should aging be considered as a single, integrated process across the scales of biological resolution, from organismal to molecular, or must we consider each level of biological scale as a separate, distinct entity? Viewing aging from these differing perspectives yields distinct but complementary interpretations about the properties and mechanisms of aging and may offer a path through the complexities related to understanding the nature of aging.
衰老的本质是什么，我们应该如何最好地研究它呢？在这里，我们通过一系列的问题，从不同的角度探讨了衰老的本质，这些问题强调了衰老相关表型之间复杂的相互作用，我们还探讨了利用黑腹果蝇在机体、组织、细胞和分子水平上的数据，如何阐明这些相互作用。衰老是否应该被视为个体随时间推移而死亡概率的增加，或者被视为一系列生理状态的进展？所有与年龄相关的生理变化都对活力有害，还是有些补偿性变化可以维持活力？为什么随着个体年龄的增长，不同的与年龄相关的功能在单个个体中似乎以不同的速度发生变化？衰老是否应该被视为跨越生物分辨率尺度（从机体到分子）的单一、综合过程，还是我们必须将每个生物学尺度的水平视为一个单独的、不同的实体？从这些不同的角度看待衰老，可以对衰老的性质和机制产生独特但互补的解释，并为理解衰老的本质提供一条途径，帮助我们应对相关的复杂性。
