Connor E, Bagarazzi M, McSherry G, Holland B, Boland M, Denny T, Oleske J
Children's Hospital AIDS Program, Children's Hospital of New Jersey, Newark 07107.
JAMA. 1991 Apr 3;265(13):1693-7.
The case histories of 27 children with Pneumocystis carinii pneumonia (PCP) who were followed up in the AIDS Program at the Children's Hospital of New Jersey, Newark, are reviewed. The mean and median age at PCP diagnosis were 10.8 and 7.7 months, respectively. All of the children had other clinical evidence of infection with the human immunodeficiency virus that was documented prior to the diagnosis of PCP or found at the time of PCP diagnosis. Most patients who presented to the hospital were acutely ill, and complications of treatment occurred in 70%. Overall, 89% of the patients died and 70% survived for less than 6 months after diagnosis of PCP. Median survival after the diagnosis of PCP was only 2.0 months and the median life span of children with PCP was only 14.4 months. Only 40% of children with PCP had CD4 lymphocyte counts at or below the threshold for institution of PCP prophylaxis in adults of 200 x 10(6) cells/L (200 cells/mm3).
回顾了在新泽西州纽瓦克市儿童医院艾滋病项目中接受随访的27例卡氏肺孢子虫肺炎（PCP）患儿的病历。PCP诊断时的平均年龄和中位年龄分别为10.8个月和7.7个月。所有患儿在PCP诊断之前或诊断时均有其他人类免疫缺陷病毒感染的临床证据。大多数入院患者病情严重，70%出现治疗并发症。总体而言，89%的患者死亡，70%在PCP诊断后存活时间不足6个月。PCP诊断后的中位生存期仅为2.0个月，PCP患儿的中位寿命仅为14.4个月。只有40%的PCP患儿CD4淋巴细胞计数达到或低于成人PCP预防阈值200×10⁶细胞/L（200细胞/mm³）。
